The International Society for Digital Imaging of the Skin (ISDIS) was founded in 1992 by a group of U.S. dermatologists, pharmaceutical and cosmetic industry scientists, radiologists, and plastic surgeons. The goal of the society is to familiarize members with new and evolving digital skin imaging technologies relevant to clinical practice. Techniques and technologies of interest to ISDIS members have included dermoscopy, telemedicine, magnetic resonance imaging, spectroscopy, optical coherence tomography, and total body imaging. The society achieves its goals through the organization of scientific meetings, a newsletter, and the journal Skin Research and Technology.  The ISDIS has partnered with the International Society for Bioengineering and the Skin (ISBS) and the International Society for Skin Imaging (ISSI) in many of its activities. As of 2005, the ISBS and ISSI have merged to form the International Society for Biophysics and the Skin (ISBS).

Conferences: The ISDIS has participated in the organization of multiple international scientific meetings. In 1993 ISDIS held a joint meeting with European Skin Ultrasound Society in Helsinore, Denmark. Between 1995 and 2002 the ISDIS held a series of very successful meetings jointly with the ISSI in New Orleans, Vienna, London, and Washington D.C..  In 2005,  ISDIS held a well attended highly acclaimed meeting in Wilmington, Delaware jointly with the ISBS and ISSI.

Beginning in 2006, the ISDIS will hold annual meetings in conjunction with the annual meeting of American Academy of Dermatology as well as biennial international meetings in partnership with the ISBS.  Since 2009 the annual ISDIS meeting has been combined with meetings of the IDS (International Dermoscopy Society) and the CWG (Confocal Working Group) as the “Tri-Society” imaging meeting, still in conjuction with the annual meeting of the American Academy of Dermatology.

Journal: In 1993 the ISDIS partnered with the ISBS and ISSI to launch a peer reviewed journal. Through the significant and sustained efforts of Jorgen Serup, Alexander Zemtsov, and others, the resulting journal- Skin Research and Technology has been a great success. Within five years of its initial publication in 1995,  Skin Research and Technology achieved a broad readership and inclusion in the Index Medicus.

International Skin Imaging Collaboration (ISIC): In 2014, the ISDIS began hosting the web presence of the ISIC, an international collaboration designed to develop and promote standards for photographic/dermoscopic skin imaging.